There is provided an optical fiber transmission-line with which the four-wave mixing generation can be suppressed effectively and also transmission loss is small. An optical fiber transmission-line 10 is dispersion-managed by a single silica optical fiber thereof being provided alternately in its longitudinal direction with parts 10a where the chromatic dispersion at the wavelength 1550 nm is positive and parts 10b where it is negative. In any one repeater span of the transmission-line there are at least four sign change positions P at which the sign of the chromatic dispersion changes in the longitudinal direction; the absolute value of the average changing rate of chromatic dispersion in each sign change locality A, each sign change locality A being a range including a sign change position P over which the absolute value of the chromatic dispersion is less than 2 ps/nm/km, is not less than 0.008 ps/nm/km/m and not greater than 4 ps/nm/km/m; the absolute value of the average value of the chromatic dispersion over the whole conduit is not greater than 2 ps/nm/km; the average value of the effective core area over the whole transmission-line is not less than 50 .mu.m.sup.2 ; the average value of the transmission loss over the whole transmission-line is not greater than 0.25 dB/km; and the average value of the polarization mode dispersion over the whole transmission-line is not greater than 0.2 ps/km/.sup.1/2.