The present invention comprises piperazine-containing compounds which inhibit prenyl-protein transferases, including farnesyl-protein transferase and geranylgeranyl-protein transferase type I. Such therapeutic compounds are useful in the treatment of cancer.

A invenção atual compreende piperazine-conter os compostos que inibem transferases da prenyl-proteína, including o tipo I do transferase da farnesyl-proteína e do transferase da geranylgeranyl-proteína. Tais compostos therapeutic são úteis no tratamento do cancer.