The present invention relates to methods of identifying compounds useful as modulators of certain stress responsive kinases. More particularly, the compounds so identified are useful for treating or preventing diseases or conditions that are mediated by, for example, abnormal bone resorption or angiogenesis. These compounds are useful for treating or preventing osteoporosis, and inhibiting vascular restenosis, diabetic retinopathy, macular degeneration, angiogenesis, atherosclerosis, inflammation, and tumor growth.

A invenção atual relaciona-se aos métodos de identificar os compostos úteis como moduladores de kinases responsivos de determinado stress. Mais particularmente, os compostos assim que identificado são úteis para tratar ou impedir as doenças ou as circunstâncias por que são mediados, para o exemplo, resorption do osso ou angiogenesis anormal. Estes compostos são úteis para tratar ou impedir o osteoporosis, e restenosis vascular inibindo, degeneration diabetic, angiogenesis, atherosclerosis, inflammation, e crescimento retinopathy, macular do tumor.