Novel pyrrolidine compounds that are potent and selective inhibitors of PDE4, as well as methods of making the same, are disclosed. Use of the compounds in the treatment of inflammatory diseases and other diseases involving elevated levels of cytokines, as well as central nervous system (CNS) disorders, also is disclosed.

Os compostos do pyrrolidine da novela que são potent e inibidores seletivos de PDE4, as.well.as métodos de fazer o mesmo, são divulgados. O uso dos compostos no tratamento de doenças inflammatory e outras de doenças que envolvem níveis elevated dos cytokines, assim como disorders do sistema nervoso central (CNS), é divulgado também.