The cDNA that encodes a glycoprotein receptor from the tobacco hornworm
which binds a Bacillus thuringiensis toxin has been obtained and
sequenced. The availability of this cDNA permits the retrieval of DNAs
encoding homologous receptors in other insects and organisms as well as
the design of assays for the cytotoxicity and binding affinity of
potential pesticides and the development of methods to manipulate natural
and/or introduced homologous receptors and, thus, to destroy target cells,
tissues and/or organisms.