Compounds of Formula I are antagonists of VLA-4 and/or .alpha.4.beta.7, and as such are useful in the inhibition or prevention of cell adhesion and cell-adhesion mediated pathologies. These compounds may be formulated into pharmaceutical compositions and are suitable for use in the treatment of AIDS-related dementia, allergic conjunctivitis, allergic rhinitis, Alzheimer's disease, asthma, atherosclerosis, autologous bone marrow transplantation, certain types of toxic and immune-based nephritis, contact dermal hypersensitivity, inflammatory bowel disease including ulcerative colitis and Crohn's disease, inflammatory lung diseases, inflammatory sequelae of viral infections, meningitis, multiple sclerosis, multiple myeloma, myocarditis, organ transplantation, psoriasis, pulmonary fibrosis, restenosis, retinitis, rheumatoid arthritis, septic arthritis, stroke, tumor metastasis, uveititis, and type I diabetes.

Os compostos da fórmula I são antagonistas de VLA-4 e/ou de alpha.4.beta.7, e porque tais são úteis na inibição ou na prevenção da adesão da pilha e de pathologies mediados pilha-adesão. Estes compostos podem ser formulados em composições pharmaceutical e são apropriados para o uso no tratamento de dementia Dae (dispositivo automático de entrada)-relacionado, conjunctivitis allergic, rhinitis allergic, doença de Alzheimer, asthma, atherosclerosis, transplantation autologous do marrow de osso, determinados tipos de tóxico e o nephritis imune-baseado, contata o hypersensitivity dermal, a doença inflammatory do bowel including o colitis ulcerative e a doença de Crohn, doenças de pulmão inflammatory, sequelae inflammatory de infecções viral, meningitis, o sclerosis múltiplo, o myeloma múltiplo, o myocarditis, o transplantation do órgão, o psoriasis, o fibrosis pulmonary, o restenosis, o retinitis, o arthritis rheumatoid, o arthritis séptico, o curso, o metastasis do tumor, o uveititis, e o tipo diabetes de I.