Immunoregulatory compounds are disclosed of the formula: ##STR1## as well as the pharmaceutically acceptable salts and hydrates thereof, are disclosed. The compounds are useful for treating immune mediated diseases and conditions, such as bone marrow, organ and tissue transplant rejection. Pharmaceutical compositions and methods of use are included.

Os compostos immunoregulatory são divulgados da fórmula: ## do ## STR1 as.well.as os sais e os hydrates pharmaceutically aceitáveis disso, são divulgados. Os compostos são úteis para tratar doenças mediadas imunes e as condições, tais como o marrow de osso, o órgão e o tecido transplant a rejeção. As composições e os métodos pharmaceutical do uso são incluídos.