Pharmaceutical compositions and compounds are provided. The compounds of the invention have anti-proliferative activity, and may promote apoptosis in cells lacking normal regulation of cell cycle and death. In one embodiment of the invention, formulations of the compounds in combination with a physiologically acceptable carrier are provided. The pharmaceutical formulations are useful in the treatment of hyperproliferative disorders, which disorders include tumor growth, lymphoproliferative diseases, angiogenesis. The compounds of the invention are substituted pyrazoles and pyrazolines.

As composições e os compostos pharmaceutical são fornecidos. Os compostos da invenção têm a atividade antiproliferativa, e podem promover o apoptosis nas pilhas que faltam o regulamento normal do ciclo e da morte da pilha. Em uma incorporação da invenção, os formulations dos compostos em combinação com um portador physiologically aceitável são fornecidos. Os formulations pharmaceutical são úteis no tratamento dos disorders hyperproliferative, que os disorders incluem o crescimento do tumor, doenças lymphoproliferative, angiogenesis. Os compostos da invenção são pyrazoles e pyrazolines substituídos.