New benzenedicarboxylic acid derivative compounds; pharmaceutical compositions, diagnostic methods, and diagnstic kits that include those compounds; and methods of using those compounds for inhibiting NAALADase enzyme activity, detecting diseases where NAALADase levels are altered, effecting neuronal activity, effecting TGF-.beta. activity, inhibiting angiogenesis, and treating glutamate abnormalities, neutopathy, pain, compulsive disorders, prostate diseases, cancers, and glaucoma.

Compostos benzenedicarboxylic novos do derivative ácido; composições pharmaceutical, métodos diagnósticos, e jogos diagnstic que incluem aqueles compostos; e métodos de usar aqueles compostos para inibir a atividade de enzyme de NAALADase, detectando as doenças onde os níveis de NAALADase são alterados, efetuando a atividade neuronal, efetuando a atividade de TGF-.beta., o angiogenesis inibindo, e o tratamento de abnormalities do glutamate, neutopathy, de dor, de disorders compulsive, de doenças do prostate, de cancers, e de glaucoma.