A compound of the formula I:
##STR1##
wherein: X is CH or N; Y is O or S; Z is OH, NH.sub.2, NMeR.sup.3,
NHR.sup.3 ; OR.sup.3 or 5- or 6-membered heterocycle, having 1 to 4
heteroatoms selected from O, N and S, said heterocycle being optionally
substituted with from 1 to 4 substituents; A is N, COR.sup.7 or CR.sup.5,
wherein R.sup.5 is H, halogen, or (C.sub.1-6) alkyl and R.sup.7 is H or
(C.sub.1-6 alkyl), with the proviso that X and A are not both N; R.sup.6
is H, halogen, (C.sub.1-6 alkyl) or OR.sup.7, wherein R.sup.7 is H or
(C.sub.1-6 alkyl);
R.sup.1 is selected from the group consisting of 5- or 6-membered
heterocycle having 1 to 4 heteroatoms selected from O, N, and S, phenyl,
phenyl(C.sub.1-3)alkyl, (C.sub.2-6)alkenyl, phenyl(C.sub.2-6)alkenyl,
(C.sub.3-6)cycloalkyl, (C.sub.1-6)alkyl, CF.sub.3, 9- or 10-membered
heterobicycle having 1 to 4 heteroatoms selected from O, N and S, wherein
said heterocycle, phenyl, phenyl(C.sub.2-6)alkenyl and
phenyl(C.sub.1-3)alkyl), alkenyl, cycloalkyl, (C.sub.1-6)alkyl, and
heterobicycle are all optionally substituted with from 1 to 4
substituents;
R.sup.2 is selected from (C.sub.1-6)alkyl, (C.sub.3-7)cycloalkyl,
(C.sub.3-7)cycloalkyl(C.sub.1-3)alkyl, (C.sub.6-10)bicycloalkyl,
adamantyl, phenyl, and pyridyl, all of which is optionally substituted
with from 1 to 4 substituents;
R.sup.3 is selected from H, (C.sub.1-6)alkyl, (C.sub.3-6)cycloalkyl,
(C.sub.3-6)cycloalkyl(C.sub.1-6)alkyl, (C.sub.6-10)aryl,
(C.sub.6-10)aryl(C.sub.1-6)alkyl, (C.sub.2-6)alkenyl,
(C.sub.3-6)cycloalkyl(C.sub.2-6)alkenyl,
(C.sub.6-10)aryl(C.sub.2-6)alkenyl, N{(C.sub.1-6) alkyl}.sub.2,
NHCOO(C.sub.1-6)alkyl(C.sub.6-10)aryl, NHCO(C.sub.6-10)aryl,
(C.sub.1-6)alkyl-5- or 10-atom heterocycle, having 1 to 4 heteroatoms
selected from O, N and S, and 5- or 10-atom heterocycle having 1 to 4
heteroatoms selected from O, N and S;
wherein said alkyl, cycloalkyl, aryl, alkenyl and heterocycle are all
optionally substituted with from 1 to 4 substituents; n is zero or 1; or a
detectable derivative or salt thereof.
The compounds of the invention may be used as inhibitors of hepatitis C
virus replication.
The invention further provides a method for treating or preventing
hepatitis C virus infection.
Un compuesto del fórmula I: ## del ## STR1 en donde: X es CH o N; Y es O o S; Z es OH, NH.sub.2, NMeR.sup.3, NHR.sup.3; OR.sup.3 o 5 o heterocycle 6-membered, teniendo 1 a 4 heteroatoms seleccionados de O, N y S, heterocycle dicho que es substituido opcionalmente con a partir 1 a 4 sustitutos; A es N, COR.sup.7 o CR.sup.5, en donde R.sup.5 es H, halógeno, o el alkyl (C.sub.1-6) y R.sup.7 son H o (el alkyl C.sub.1-6), a condición de que X y A no es amba N; R.sup.6 es H, halógeno, (el alkyl C.sub.1-6) u OR.sup.7, en donde R.sup.7 es H o (el alkyl C.sub.1-6); R.sup.1 se selecciona del grupo que consiste en 5 o el heterocycle 6-membered que tiene 1 a 4 heteroatoms seleccionados de O, de N, y de S, fenilo, phenyl(C.sub.1-3)alkyl, (C.sub.2-6)alkenyl, phenyl(C.sub.2-6)alkenyl, (C.sub.3-6)cycloalkyl, (C.sub.1-6)alkyl, CF.sub.3, 9 o el heterobicycle 10-membered teniendo 1 a 4 heteroatoms seleccionados de O, de N y de S, en donde heterocycle, fenilo, phenyl(C.sub.2-6)alkenyl y phenyl(C.sub.1-3)alkyl) dichos, alkenyl, cycloalkyl, (C.sub.1-6)alkyl, y el heterobicycle son todos substituido opcionalmente con a partir 1 a 4 sustitutos; R.sup.2 se selecciona de (C.sub.1-6)alkyl, (C.sub.3-7)cycloalkyl, (C.sub.3-7)cycloalkyl(C.sub.1-3)alkyl, (C.sub.6-10)bicycloalkyl, adamantyl, fenilo, y el pyridyl, que se substituye opcionalmente con a partir 1 a 4 sustitutos; R.sup.3 se selecciona de H, (C.sub.1-6)alkyl, (C.sub.3-6)cycloalkyl, (C.sub.3-6)cycloalkyl(C.sub.1-6)alkyl, (C.sub.6-10)aryl, (C.sub.6-10)aryl(C.sub.1-6)alkyl, (C.sub.2-6)alkenyl, (C.sub.3-6)cycloalkyl(C.sub.2-6)alkenyl, (C.sub.6-10)aryl(C.sub.2-6)alkenyl, N{(C.sub.1-6) alkyl}.sub.2, NHCOO(C.sub.1-6)alkyl(C.sub.6-10)aryl, NHCO(C.sub.6-10)aryl, (heterocycle de C.sub.1-6)alkyl-5- o del 10-a'tomo, teniendo 1 a 4 heteroatoms seleccionados de O, N y S, y heterocycle de 5 o del 10-a'tomo que tiene 1 a 4 heteroatoms seleccionados de O, de N y de S; en donde el alkyl, el cycloalkyl, el aryl, el alkenyl dicho y el heterocycle son todo substituidos opcionalmente con a partir 1 a 4 sustitutos; n es cero o 1; o un derivado o una sal perceptible de eso. Los compuestos de la invención se pueden utilizar como inhibidores de la réplica del virus de la hepatitis C. La invención más futura proporciona un método para tratar o prevenir la infección del virus de la hepatitis C.
