A method is provided for the localized intravascular administration of a fibrinolytic metalloproteinase to a human subject in amounts that are both safe and effective to lyse an occluding fibrin-containing blood clot, while also avoiding the neutralizing effects of .alpha..sub.2 -macroglobulin in the circulating blood.

Um método é fornecido para a administração intravenosa localizada de um metalloproteinase fibrinolítico a um assunto humano nas quantidades que são seguras e eficazes lyse um clot de sangue fibrin-contendo occluding, ao também evitar os efeitos neutralizando do alpha..sub.2 - macroglobulin no sangue circulando.

 
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< Polynucleotides encoding human glial cell line-derived neurotrophic factor receptor polypeptides

> Biodegradable pH/thermosensitive hydrogels for sustained delivery of biologically active agents

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