The invention concerns amide derivatives of formula (I) ##STR1## wherein R.sup.3 is (1-6C)alkyl or halogeno; m is 0-3, p is 0-2 and q is 0-4; each of R.sup.1 and R.sup.2 is a group such as hydroxy, halogeno, trifluoromethyl and cyano; R.sup.4 is a basic group such as amino, (1-6C)alkylamino, di-[(1-6C)alkyl]amino, di-[(1-6C)alkyl]amino-(1-6C)alkyl, di-[(1-6C)alkyl]amino-(2-6C)alkoxy, heteroaryl, heteroaryloxy, heteroaryl-(1-6C)alkoxy, heterocyclyl, heterocyclyloxy and heterocyclyl-(1-6C)alkoxy; and Q.sup.2 is a group such as heteroaryl, heteroaryloxy or heteroaryl-(1-6C)alkoxy which is optionally substituted; or pharmaceutically-acceptable salts or in-vivo-cleavable esters thereof; processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of diseases or medical conditions mediated by cytokines.

De uitvinding betreft amidederivaten van formule (I) ## STR1 ## waarin R.sup.3 is (1-6C)alkyl of halogeno; m is 0-3, is p 0-2 en q is 0-4; elk van R.sup.1 en R.sup.2 is een groep zoals hydroxy, halogeno, trifluoromethyl en cyano; R.sup.4 is een basisgroep zoals amino, (1-6C)alkylamino, Di-[(1-6C)alkyl]amino, Di-[(1-6C)alkyl]amino-(1-6C)alkyl, Di-[(1-6C)alkyl]amino-(2-6C)alkoxy, heteroaryl, heteroaryloxy, heteroaryl-(1-6C)alkoxy, heterocyclyl, heterocyclyloxy en heterocyclyl-(1-6C)alkoxy; en Q.sup.2 is een groep zoals heteroaryl, heteroaryloxy of heteroaryl-(1-6C)alkoxy die naar keuze worden gesubstitueerd; of pharmaceutically-acceptable zouten of in-vivo-splijtbare esters daarvan; processen voor hun voorbereiding, farmaceutische samenstellingen die hen en hun gebruik in de behandeling van ziekten bevatten