A method is provided for genetically modifying primate bone marrow cells,
comprising isolating bone marrow cells from a primate and, by means which
enhance the local concentration of retroviral contacting the isolated bone
marrow cells to cells that produce a recombinant amphotropic retrovirus
with a genome based on a retroviral vector that contains the genetic
information to be introduced into the bone marrow cells. Recombinant
amphotropic retrovirus-producing cells, suitable for use in this method
also are provided, as are genetically modified primate bone marrow cells
with the capacity for regeneration in vivo.