The invention relates to substituted polycyclic aryl and heteroaryl tertiary-heteroalkylamine compounds useful as inhibitors of cholesteryl ester transfer protein (CETP; plasma lipid transfer protein-I) and compounds, compositions and methods for treating atherosclerosis and other coronary artery diseases. Preferred tertiary-heteroalkylamine compounds are substituted N,N-bis-benzyl aminoalcohols. A preferred specific N,N-bis-benzyl aminoalcohol is the compound: ##STR1##

La invención se relaciona con los compuestos terciarios-heteroalkylamine policíclicos substituidos del aryl y del heteroaryl útiles mientras que los inhibidores del éster del cholesteryl transfieren la proteína (CETP; protei'na-Yo de la transferencia del lípido del plasma) y compuestos, composiciones y métodos para tratar atherosclerosis y otras enfermedades de la arteria coronaria. Los compuestos terciarios-heteroalkylamine preferidos son N substituida, aminoalcoholes N-bis-n-bis-benzyl. Una N específica preferida, aminoalcohol N-bis-n-bis-benzyl es el compuesto: ## del ## STR1

 
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