The present invention relates to a novel class of covalently coupled benzoylecgonine, ecgonine and ecgonidine derivatives that are useful for alleviating the symptoms of immunoregulatory disorders, neuromuscular disorders, joint disorders, connective tissue disorders, circulatory disorders and pain. Accordingly, this invention also relates to pharmaceutical compositions and methods for their use.

A invenção atual relaciona-se a uma classe da novela dos derivatives covalently acoplados do benzoylecgonine, do ecgonine e do ecgonidine que são úteis para aliviar os sintomas de disorders immunoregulatory, de disorders neuromuscular, de disorders comuns, de disorders do tecido conexivo, de disorders circulatory e de dor. Conformemente, esta invenção relaciona-se também às composições e aos métodos pharmaceutical para seu uso.