Compounds according formula (I)
A--G--Z--W
and pharmaceutically acceptable salts, solvates or hydrates thereof;
wherein,
A is (C.sub.6 -C.sub.10)aryl, (C.sub.6 -C.sub.10)aryl-SO.sub.2, (C.sub.6
-C.sub.10)aryl-CH.sub.2 --, (C.sub.6 -C.sub.10)arylcarbonyl, (C.sub.1
-C.sub.9)heteroaryl, (C.sub.1 -C.sub.9)heteroaryl-SO.sub.2 --, (C.sub.1
-C.sub.9)heteroaryl-CH.sub.2 --; or (C.sub.1 -C.sub.9)heteroarylcarbonyl;
G is selected from the group consisting of:
##STR1##
where B is (C.sub.6 -C.sub.10)aryl or (C.sub.1 -C.sub.9)heteroaryl, and X
is CH.sub.2, SO.sub.2, or carbonyl;
##STR2##
where X is CH.sub.2, SO.sub.2, or carbonyl; and R.sup.1 and R.sup.1' are
each independently selected from H, CN, (C.sub.1 -C.sub.8)alkyl-, and
phenyl(CH.sub.2)--, wherein said alkyl and phenyl groups are optionally
substituted; and
##STR3##
where Z and W are as defined in the present Specificiation; and
pharmaceutical compositions and methods useful to increase secretion of
growth hormone(GH) from the anterior pituitary of mammals, including on a
sustained release basis.
Смеси согласовывая формулу (I) а -- г -- з -- ш и фармацевтически приемлемо соли, solvates или гидраты thereof; при котором, А (C.sub.6 - C.sub.10)aryl, (C.sub.6 - C.sub.10)aryl-SO.sub.2, (C.sub.6 - C.sub.10)aryl-CH.sub.2 --. (C.sub.6 - C.sub.10)arylcarbonyl, (C.sub.1 - C.sub.9)heteroaryl, (C.sub.1 - C.sub.9)heteroaryl-SO.sub.2 --. (C.sub.1 - --; C.sub.9)heteroaryl-CH.sub.2 или (C.sub.1 - C.sub.9)heteroarylcarbonyl; Г выбран от consist of группы: ## ## STR1 где б (C.sub.6 - C.sub.10)aryl или (C.sub.1 - C.sub.9)heteroaryl, и х будут CH.sub.2, SO.sub.2, или карбонилом; ## ## STR2 где х будет CH.sub.2, SO.sub.2, или карбонилом; и R.sup.1 и R.sup.1 ' каждое независимо выбранное от ю, CN, (C.sub.1 - C.sub.8)alkyl -, и phenyl(CH.sub.2) --. при котором сказанный алкил и фениловые группы опционно заменены; и ## ## STR3 где з и ш как определено в присытствыющем Specificiation; и фармацевтические составы и методы полезные для того чтобы увеличить секретирование hormone(GH) роста от anterior pituitary mammals, вклюающ на, котор вытерпели основание отпуска.
