The invention provides novel peptide prodrugs which contain cleavage sites specifically cleaved by prostate specific antigen (PSA). These prodrugs are useful for substantially inhibiting the non-specific toxicity of a variety of therapeutic drugs. PSA is secreted by prostatic glandular cells. Upon cleavage of the prodrug by PSA, the therapeutic drugs are activated and exert their toxicity. Novel sesquiterpene-.gamma.-lactones are also provided by the invention, and are designed to be linked to carrier moieties such as the peptides of the invention. Methods for treating cell proliferative disorders are also featured in the invention.

A invenção fornece os prodrugs do peptide da novela que contêm os locais do cleavage cleaved especificamente pelo antígeno específico do prostate (PSA). Estes prodrugs são úteis para substancialmente inibir o toxicity non-specific de uma variedade de drogas therapeutic. PSA secreted por pilhas glandular prostatic. Em cima do cleavage do prodrug por PSA, as drogas therapeutic são ativadas e exercem seu toxicity. A novela sesquiterpene-.gamma.-lactones é fornecida também pela invenção, e projetada ser ligada aos moieties de portador tais como os peptides da invenção. Os métodos para tratar disorders proliferative da pilha são caracterizados também na invenção.