The present invention relates to methods for treating alopecia and stimulating hair growth and pharmaceutical compositions using nonimmunosuppressive [.gamma.-hydroxy-methylleucine.sup.4 ] cyclosporin A having superior hair growth-promoting effect, wherein the hydroxyl group is added to the carbon position of No. 4 methylleucine of cyclosporin A by the microorganism.

A invenção atual relaciona-se aos métodos para tratar o alopecia e estimular as composições do crescimento do cabelo e as pharmaceutical usando o cyclosporin [ gamma.-gamma.-hydroxy-methylleucine.sup.4-methylleucine.sup.4 ] nonimmunosuppressive A que tem o efeito growth-promoting do cabelo superior, wherein o grupo do hydroxyl é adicionado à posição do carbono do methylleucine do no. 4 do cyclosporin A pelo microorganism.