The invention provides transgenic non-human animals and transgenic non-human mammalian cells harboring a transgene encoding an APP polypeptide comprising the Swedish mutation.

 
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< .beta.-secretase antibody

< Transgenic rodents harboring APP allele having Swedish mutation

> Assay for Alzheimer's disease drug development

> Antibodies and fragments thereof which bind the carboxyl-terminus of an amino-terminal fragment of .beta.APP
~ 00064