This invention provides compounds of Formula (I), having the structure ##STR1## where T, Z, X, A, R.sup.1, R.sup.2a, R.sup.2b, R.sup.2c, R.sup.3, R.sup.4, and n are defined herein, or a pharmaceutically acceptable salt thereof which are useful as antineoplastic agents and in the treatment of osteoporosis and polycystic kidney disease.

Esta invenção fornece compostos da fórmula (i), tendo o ## do ## STR1 da estrutura onde T, Z, X, A, R.sup.1, R.sup.2a, R.sup.2b, R.sup.2c, R.sup.3, R.sup.4, e n são definidos nisto, ou um sal pharmaceutically aceitável disso que são úteis como agentes antineoplastic e no tratamento do osteoporosis e da doença polycystic do kidney.