The present invention relates to compounds of formula (I) wherein R.sub.1 and R.sub.2 independently represent one or more, same or different substituents selected from the group consisting of halogen, hydroxy, mercapto, trifluoromethyl, amino (C.sub.1 -C.sub.3)alkyl, (C.sub.2 -C.sub.3)olefinic group, (C.sub.1 -C.sub.3)alkoxy, (C.sub.1 -C.sub.3)alkylthio, (C.sub.1 -C.sub.6)alkylamino, (C.sub.1 -C.sub.3)alkoxycarbonyl, cyano, carbamoyl, phenyl, or nitro; R.sub.2 further being represented by hydrogen; R.sub.3 represents hydrogen, halogen, hydroxy, mercapto, trifluoromethyl, amino, (C.sub.1 -C.sub.3)alkyl, (C.sub.2 -C.sub.3)olefinic group, (C.sub.1 -C.sub.3)alkoxy, (C.sub.1 -C.sub.3)alkylthio, (C.sub.1 -C.sub.6)alkylamino, (C.sub.1 -C.sub.3)alkoxycarbonyl, phenyl, cyano, carboxy or carbomoyl; R.sub.4 represents hydrogen, (C.sub.1 -C.sub.3)alkyl, or allyl; X represents oxygen or sulpher; with the proviso that formula (I) does not comprise the compound 2,2,2-trifluoro-N-[2-[3-chloro-4-(2-methylbenzoyl)-phenylamino]-phenyl]ace tamide wherein R.sub.1 is a 2-methyl, R.sub.2 is 2-chloro, R.sub.3 and R.sub.4 is hydrogen, and X is oxygen; and a salt thereof with a pharmaceutically acceptable acid, a hydrate or a solvate thereof. The compounds are valuable in the human and veterinary therapy. ##STR1##

La actual invención se relaciona con los compuestos del fórmula (i) en donde R.sub.1 y R.sub.2 representan independientemente uno o más, mismos o de diversos sustitutos seleccionados del halógeno que consiste en del grupo, hydroxy, mercapto, trifluoromethyl, amino (C.sub.1 - C.sub.3)alkyl, (C.sub.2 - grupo de C.sub.3)olefinic, (C.sub.1 - C.sub.3)alkoxy, (C.sub.1 - C.sub.3)alkylthio, (C.sub.1 - C.sub.6)alkylamino, (C.sub.1 - C.sub.3)alkoxycarbonyl, cyano, carbamoyl, fenilo, o nitro; R.sub.2 fomentan la representación por el hidrógeno; R.sub.3 representa el hidrógeno, halógeno, hydroxy, mercapto, trifluoromethyl, amino, (C.sub.1 - C.sub.3)alkyl, (C.sub.2 - grupo de C.sub.3)olefinic, (C.sub.1 - C.sub.3)alkoxy, (C.sub.1 - C.sub.3)alkylthio, (C.sub.1 - C.sub.6)alkylamino, (C.sub.1 - C.sub.3)alkoxycarbonyl, fenilo, cyano, carboxy o carbomoyl; R.sub.4 representa el hidrógeno, (C.sub.1 - C.sub.3)alkyl, o alílico; X representa el oxígeno o el sulpher; a condición de que el fórmula (i) no abarque el tamide compuesto 2,2,2-trifluoro-N-[2-[3-chloro-4-(2-methylbenzoyl)-phenylamino]-phenyl]ace en donde R.sub.1 es un 2-methyl, R.sub.2 es 2-chloro, R.sub.3 y R.sub.4 es hidrógeno, y X es oxígeno; y una sal de eso con un ácido farmacéutico aceptable, un hidrato o un solvate de eso. Los compuestos tienen valores en la terapia humana y veterinaria. ## del ## STR1