The invention relates to novel compounds comprising a ubiquitination recognition element and a protein binding element. The invention also relates to the use of said compounds for modulating the level and/or activity of a target protein. The compounds are useful for the treatment of disease such as infections, inflammatory conditions, cancer and genetic diseases. The compounds are also useful as insecticides and herbicides.

A invenção relaciona-se aos compostos da novela que compreendem um elemento do recognition do ubiquitination e um elemento obrigatório da proteína. A invenção relaciona-se também ao uso de compostos ditos para modular o nível e/ou a atividade de uma proteína do alvo. Os compostos são úteis para o tratamento da doença tal como infecções, circunstâncias inflammatory, cancer e doenças genetic. Os compostos são também úteis como insecticides e herbicides.

 
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< Latent reactive blood compatible agents

< CALCIUM COMPLEX OF [[(4R)-4-[BIS{CARBOXY-.KAPPA.O)METHYL]AMINO-.KAPPA.N]-6,9-BIS[(CARBOXY. KAPPA. O)METHYL]-1-[(4,4-DIPHENYLCYCLOHEXYL)OXY]-1-HYDROXY-2-OXA-6,9-DIAZA-1-PHOS PHAUNDECAN-11-YLIC-ACID-.KAPPA.N6,.KAPPA.N9,.KAPPA.011]1-OXIDATO(6-)]-, HEXAHYDROGEN, ITS SALTS, PHARMACEUTICAL AGENTS THAT CONTAIN THESE COMPLEXES, THEIR USE IN TREATMENT AND AS ADDITIVES IN DIAGNOSIS, AS WELL AS PROCESSES FOR THE PRODUCTION OF THE COMPLEXES AND AGENTS

> Mycobacterium fol A gene that encodes for the enzyme dihydrofolate reductase

> Non-toxic antimicrobial compositions and methods of use

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