Disclosed are a polypeptide (including that in soluble form) as receptor for a novel cytokine, i.e., interleukin-18, a DNA encoding the polypeptide, and the uses of the polypeptide including pharmaceutical and neutralizer to interleukin-18. Pharmaceuticals with the polypeptide is useful to treat and prevent autoimmune and allergic disease because it suppresses and regulates excessive immunoreaction.

Se divulga un polipéptido (eso incluyendo en forma soluble) como receptor para un cytokine de la novela, es decir, interleukin-18, una DNA que codifica el polipéptido, y las aplicaciones del polipéptido incluyendo farmacéutico y del neutralizador a interleukin-18. Los productos farmacéuticos con el polipéptido son útiles para tratar y para prevenir enfermedad autoinmune y alérgica porque suprime y regula el immunoreaction excesivo.

 
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