The present invention includes 16-HETE analogs which are agonists and antagonists of 16-HETE. The compositions may be formulated in pharmaceutically acceptable formulations. The invention also includes methods and products for inhibiting neutrophil adhesion and neutrophil aggregation using the 16-HETE agonists. One method of the invention involves the administration of a 16-HETE agonist in combination with a thrombolytic agent to a patient suffering from thromboembolic stroke.

De onderhavige uitvinding omvat analogons 16-HETE die agonists en antagonisten van 16-HETE zijn. De samenstellingen kunnen in farmaceutisch aanvaardbare formuleringen worden geformuleerd. De uitvinding omvat ook methodes en producten voor het remmen van neutrophil adhesie en neutrophil samenvoeging gebruikend agonists 16-HETE. Één methode van de uitvinding houdt het beleid van agonist 16-HETE in combinatie met een thrombolytic agent aan een patiënt in die aan thromboembolic slag lijdt.
 
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