Methods of preparing an amino-substituted-tetrahydroisoquinoline-sulfonamide hydroxamic acid include the steps of providing an amino-substituted-tetrahydroisoquinoline-carboxylate attached to a solid support; reacting the ring nitrogen of the amino-tetrahydroisoquinoline-carboxylate with a sulfonyl chloride; and cleaving the intermediate from the solid support to form an amino-tetrahydroisoquinoline-sulfonamide hydroxamic acid.

I metodi di preparazione dell'acido idrossamico del amminico-sostitu-tetrahydroisoquinoline-sulfamidico includono i punti di fornire un amminico-sostitu-tetrahydroisoquinoline-carbossilato fissato ad un supporto solido; reagendo l'azoto dell'anello del amminico-tetrahydroisoquinoline-carbossilato con un cloruro di sulfonyl; e fendendo l'intermediario dal supporto solido per formare un acido idrossamico del amminico-tetrahydroisoquinoline-sulfamidico.