Aminobutylic acid derivatives of the formula (I) ##STR1## wherein the symbols are as defined in specification; and non-toxic salts thereof. Because of inhibiting matrix metalloproteinase, the compounds of the formula (I) are useful for prevention and/or treatment of diseases, for example, rheumatoid diseases, arthrosteitis, osteoarthritis, unusual bone resorption, osteoporosis, periodontitis, interstitial nephritis, arteriosclerosis, pulmonary emphysema, cirrhosis, cornea injury, cornea ulcer, metastasis, invasion or growth of tumor cells, autoimmune disease, disease caused by vascular emigration or infiltration of leukocytes, arterialization, multiple sclerosis, arota aneurysm, endometriosis, restenosis after PTCA, unstable angina, acute myocardial infarction, transient ischemic attack.

Derivatives ácidos de Aminobutylic do ## do ## STR1 da fórmula (I) wherein os símbolos são como definidos na especificação; e sais non-toxic disso. Por causa do metalloproteinase inibindo da matriz, os compostos da fórmula (I) são úteis para a prevenção e/ou o tratamento das doenças, para o exemplo, doenças rheumatoid, arthrosteitis, osteodistrofia, resorption incomun do osso, osteoporosis, periodontitis, nephritis intersticial, arteriosclerosis, emphysema pulmonary, cirrhosis, ferimento do cornea, ulcer do cornea, metastasis, invasão ou crescimento de pilhas do tumor, doença autoimmune, doença causada pelo emigration vascular ou infiltration dos leukocytes, arterialization, sclerosis múltiplo, aneurysm do arota, endometriosis, restenosis após PTCA, angina instável, infarction myocardial agudo, ataque isquêmico transiente.