The present invention relates to a method for preparing 5- and 6-halomethyl quinoxalines. The method comprises contacting a 5- or 6-methyl quinoxaline with a halogenating agent in the presence of a radical initiator in a solvent selected from the group consisting of fluorobenzene, difluorobenzenes, trifluorobenzenes, chlorobenzene, dichlorobenzenes, trichlorobenzenes, .alpha., .alpha., .alpha.-trifluorotoluene and .alpha., .alpha., .alpha.-trichlorotoluene. The invention also relates to preparing 6-bromomethyl quinoxaline with N-bromosuccinimide in the presence of a radical initiator in 1,2-dichloroethane. The method for halogenating benzylic methyl groups may also be employed to halogenate a wide variety of halomethyl heterocyclic compounds.

A invenção atual relaciona-se a um método para preparar 5- e quinoxalines 6-halomethyl. O método compreende contatar uns 5- ou um quinoxaline 6-methyl com um agente halogenating na presença de um iniciador radical em um solvente selecionado do fluorobenzene do grupo, dos difluorobenzenes, dos trifluorobenzenes, do clorobenzeno, dos dichlorobenzenes, dos trichlorobenzenes, do alpha., do alpha., do alpha.-trifluorotoluene e do alpha. consistindo, alpha., alpha.-trichlorotoluene. A invenção relaciona-se também a preparar o quinoxaline 6-bromomethyl com o N-bromosuccinimide na presença de um iniciador radical em 1,2-dichloroethane. O método para halogenating grupos methyl benzylic pode também ser empregado para halogenate uma variedade larga de compostos heterocyclic do halomethyl.