Disclosed herein is sustained-release formulations of tramadol comprising tramadol saccharinate coated with at least one sustained-release coating. The sustained release formulations may also contain tramadol in non-sustained release form, and other pharmaceutically acceptable excipients. Also disclosed are methods of preparation of and methods of treatment using the inventive formulations.

É divulgado nisto sustent-libera formulations do tramadol compreender o saccharinate do tramadol revestido com ao menos o um sustent-libera revestir. Os formulations sustentados da liberação podem também conter o tramadol no formulário non-sustained da liberação, e outros excipients pharmaceutically aceitáveis. São divulgados também os métodos da preparação de e dos métodos de tratamento usando os formulations inventive.