This invention discloses
1.alpha.-hydroxy-2-methylene-19-nor-homopregnacalciferol and
pharmaceutical uses therefor. This compound exhibits pronounced activity
in arresting the proliferation of undifferentiated cells and inducing
their differentiation to the monocyte thus evidencing use as an
anti-cancer agent and for the treatment of skin diseases such as psoriasis
as well as skin conditions such as wrinkles, slack skin, dry skin and
insufficient sebum secretion. This compound also has little, if any,
calcemic activity and therefore may be used to treat immune disorders in
humans as well as renal osteodystrophy.