The present invention provides a human gene sequence that encodes the CDDP-1 polypeptide, which is involved in cell differentiation, in particular differentiation of undifferentiated progenitor cells into neutrophils, monocytes/macrophages, mast cells, and/or erythroid cells. Assays for detecting CDDP-1 expression, vectors that express CDDP-1, methods for using CDDP-1 to induce or promote cell differentiation, and transgenic animals deficient in one or both CDDP-1 alleles are described.

La presente invenzione fornisce una sequenza umana che mette il polipeptide in codice CDDP-1, che รจ coinvolto nella differenziazione delle cellule, in particolare differenziazione del gene di undifferentiated le cellule del progenitor nei neutrofili, monocytes/macrophages, cellule dell'albero e/o cellule del erythroid. Le analisi per la rilevazione l'espressione CDDP-1, i vettori che esprimono CDDP-1, metodi per usando CDDP-1 per indurre o promuovere la differenziazione delle cellule e degli animali transgenic carenti in un o entrambe l'allele CDDP-1 sono descritte.

 
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