The present provides structurally related enzymes that act as enoyl reductases. These enoyl reductases share a common amino acid consensus sequence, and bind a flavin cofactor. One particular enoyl reductase provided, FabK, catalyzes the identical reaction as the NADH-dependent enoyl-ACP reductase, FabI. Nucleic acids encoding the enoyl reductases, the enoyl reductases, and anitbodies for the enoyl reductases are also included. Methods are also provides for identifying agents that can act to prevent and/or treat bacterial infections.

Il presente fornisce gli enzimi strutturalmente riferiti che fungono da reductases di enoyl. Questi reductases di enoyl ripartiscono una sequenza comune di consenso dell'amminoacido e legano un cofattore di flavin. Una riduttasi particolare di enoyl ha fornito, FabK, catalizza la reazione identica come la riduttasi NADH-DIPENDENTE di enoyl-ACP, FabI. Gli acidi nucleici che mettono i reductases di enoyl, i reductases di enoyl ed i anitbodies in codice per i reductases di enoyl inoltre sono inclusi. I metodi sono inoltre provvede ad identificare gli agenti che possono comportarsi per impedire e/o trattare le infezioni batteriche.

 
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