Amino acid di- and tri-peptide analogs having C-terminal vinylic groups, pharmaceutical compositions containing the analogs and methods of treating diseases using cysteinyl protease inhibitors; particularly neurodegenerative, autoimmune, cognitive disorders, stroke and traumatic injury.

Acide aminé analogues di-- et de tripeptide ayant les groupes vinylic de C-borne, compositions pharmaceutiques contenant les analogues et les méthodes de traiter les maladies en utilisant des inhibiteurs de protéase de cysteinyl ; désordres particulièrement neurodegenerative, autoimmuns, cognitifs, course et dommages traumatiques.

 
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< Modulation of .gamma.-secretase activity

< Catalytic monoclonal antibodies with protease activity for selective lysis of protein component of plaques aggregates pathological conditions

> Gene-targeted mice with humanized A.beta. sequence and Swedish FAD mutation

> Genes expressed in alzheimer's disease

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