Thiazolo-, oxazolo- and selenazolo[4,5-c]quinolin-4-amines and analogs thereof are described including methods of manufacture and the use of novel intermediates. The compounds are immunomodulators and induce cytokine biosynthesis, including interferon and/or tumor biosynthesis, necrosis factor, and inhibit the T-helper-type 2 immune response. The compounds are further useful in the treatment of viral and neoplastic diseases.

Thiazolo -, o oxazolo- e selenazolo[4,5-c]quinolin-4-amines e os analogs disso são descritos including métodos da manufatura e do uso de intermediários da novela. Os compostos são immunomodulators e induzem o biosynthesis do cytokine, including o interferon e/ou o biosynthesis do tumor, fator do necrosis, e inibem o T-ajudante-tipo 2 resposta imune. Os compostos são mais mais úteis no tratamento de doenças viral e neoplastic.