Compounds of the formula I
##STR1##
or a pharmaceutically acceptable salt, solvate or N-oxide thereof, wherein
X is .dbd.CH-- or .dbd.N--;
Y is H, halogen, trihaloalkyl, alkyl, alkenyl, cycloalkyl, cycloalkyl, SH,
--S-alkyl, or --CN.
R is alkyl, --CF.sub.3, cycloalkyl, heterocycloalkyl,
heterocycloalkyl-alkyl, heteroarylalky or adamantyl, or optionally
substituted phenyl, phenoxyalkyl, phenylthioalkyl, pyridyl, thienyl,
thiazolyl, pyrazinyl, 1,2,5,6-tetrahydropyridine or
##STR2##
wherein R.sup.10 and R.sup.11 are hydrogen, alkyl or together form a
cycloalkyl, are disclosed, as well as pharmaceutical compositions and
methods of using said compounds in the treatment of eating disorders and
diabetes.
Os compostos do ## do ## STR1 da fórmula I ou de um sal pharmaceutically aceitável, o solvate ou o N-óxido disso, wherein X é dbd.CH -- ou o --; Y do dbd.N são H, halogênio, trihaloalkyl, alkyl, alkenyl, cycloalkyl, cycloalkyl, SH, -- S-s-alkyl, ou --CN. R é alkyl, -- CF.sub.3, o cycloalkyl, o heterocycloalkyl, o heterocycloalkyl-heterocycloalkyl-alkyl, heteroarylalky ou adamantyl, ou phenyl, phenoxyalkyl, phenylthioalkyl, pyridyl, thienyl, thiazolyl, pyrazinyl, 1,2,5,6-tetrahydropyridine ou ## opcionalmente substituído wherein R.sup.10 e R.sup.11 são hidrogênio, alkyl do ## STR2 ou dão forma junto a um cycloalkyl, são divulgados, as.well.as composições e métodos pharmaceutical de usar compostos ditos no tratamento de comer disorders e diabetes.