Novel pyrrolo[2,3-d]pyrimidine compounds useful as inhibitors of the enzyme protein tyrosine kinases such as Janus Kinase 3 as well as immunosuppressive agents for organ transplants, lupus, multiple sclerosis, rheumatoid arthritis, psoriasis, Type I diabetes and complications from diabetes, cancer, asthma, atopic dermatitis, autoimmune thyroid disorders, ulcerative colitis, Crohn's disease, Alzheimer's disease, Leukemia and other autoimmune diseases are described.

A novela pyrrolo[2,3-d]pyrimidine combina útil como inibidores dos kinases do tyrosine da proteína de enzyme tais como o kinase 3 de Janus assim como os agentes immunosuppressive para transplants do órgão, lupus, o sclerosis múltiplo, o arthritis rheumatoid, o psoriasis, o tipo diabetes de I e as complicações do diabetes, do cancer, do asthma, da dermatite atópica, dos disorders autoimmune do thyroid, do colitis ulcerative, da doença de Crohn, da doença de Alzheimer, do leukemia e de outras doenças autoimmune são descritos.