Isolated proteins, designated SdrF, SdrG and SdrH, and their corresponding amino acid and nucleic acid sequences are provided which are useful in the prevention and treatment of infection caused by coagulase-negative staphylococcal bacteria such as S. epidermidis. The SdrF, SdrG and SdrH proteins are cell-wall associated proteins that specifically bind host proteins and which each have a highly conserved motif of which the consensus sequence is TYTFTDYVD (SEQ ID NO:16). The proteins, antigenic portions thereof and anti-SdrF, SdrG and SdrH antibodies are also useful for the identification and diagnosis of coagulase-negative staphylococcal infections. In particular, the proteins are advantageous because they may be used as vaccine components or antibodies thereof, and they may be administered to wounds or used to coat biomaterials to act as blocking agents to prevent or inhibit the binding of coagulase-negative staphylococci to wounds or biomaterials.

As proteínas isoladas, designadas SdrF, SdrG e SdrH, e suas seqüências correspondentes do amino-ácido e o nucleic do ácido são fornecidas que são úteis na prevenção e no tratamento da infecção causados pelas bactérias staphylococcal coagulase-negative tais como o epidermidis do S.. As proteínas de SdrF, de SdrG e de SdrH são as proteínas associadas cell-wall que ligam especificamente proteínas do anfitrião e que cada uma tem um motif altamente conservado de que a seqüência do consenso é TYTFTDYVD (ID SEQ NO:16). As proteínas, as parcelas antigenic disso e o anti-SdrF, os antibodies de SdrG e de SdrH são também úteis para a identificação e o diagnóstico de infecções staphylococcal coagulase-negative. No detalhe, as proteínas são vantajosas porque podem ser usadas como componentes ou antibodies vacinais disso, e podem ser administradas às feridas ou ser usadas revestir biomaterials para agir como agentes de obstrução para impedir ou inibir o emperramento de staphylococci coagulase-negative às feridas ou aos biomaterials.

 
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