Described herein is a method for potentiating the action of a serotonin reuptake inhibitor in increasing the availability of serotonin, norepinephrin and dopamine in the brain, by administering to a patient an effective amount of a compound of the formula ##STR1## wherein Ar' is a mono or bicyclic aryl or heteroaryl radical substituted with one to three substituents selected from the group consisting of hydrogen, (C.sub.1 -C.sub.6)alkyl, (C.sub.1 -C.sub.6)alkoxy, (C.sub.1 -C.sub.6)alkylthio, (C.sub.2 -C.sub.6)alkenyl, (C.sub.2 -C.sub.6)alkynyl, (C.sub.1 -C.sub.6)alkylhalo, (C.sub.3 -C.sub.8)cycloalkyl, (C.sub.3 -C.sub.8)cycloalkenyl or halo; R.sup.1 is hydrogen, (C.sub.1 -C.sub.6)alkyl, (C.sub.1 -C.sub.6)alkoxy, (C.sub.1 -C.sub.6)alkylthio; R.sup.2 is phenyl, naphthyl or (C.sub.3 -C.sub.12)cycloalkyl substituted with one or two substituents selected from the group consisting of hydrogen (C.sub.1 -C.sub.6)alkyl, (C.sub.1 -C.sub.6)alkoxy, (C.sub.1 -C.sub.6)alkylthio, (C.sub.2 -C.sub.6)alkenyl, (C.sub.2 -C.sub.6)alkynyl, (C.sub.1 -C.sub.6)alkylhalo, (C.sub.3 -C.sub.8)cycloalkyl, (C.sub.3 -C.sub.8)cycloalkenyl or halo; R.sup.3 is selected from the group consisting of hydrogen (C.sub.1 -C.sub.6)alkyl, (C.sub.1 -C.sub.6)alkoxy, (C.sub.1 -C.sub.6)alkylthio, (C.sub.2 -C.sub.6)alkenyl, (C.sub.2 -C.sub.6)alkynyl, (C.sub.1 -C.sub.6)alkylhalo, (C.sub.3 -C.sub.8)cycloalkyl, (C.sub.3 -C.sub.8)cycloalkenyl or halo; X is --(C.dbd.O)--; or a pharmaceutically acceptable salt, racemate, optical isomer or solvate thereof.

Hierin beschrieben eine Methode für das Ermöglichen der Tätigkeit eines Serotonin reuptake Hemmnisses, wenn man die Verwendbarkeit des Serotonins, des norepinephrin und des Dopamins im Gehirn erhöht, indem man auf einen Patienten ein wirkungsvolle Menge eines Mittels des Formel ## STR1 ##, worin Ar ' ein Mono- oder bizyklisches Aryl- oder heteroaryl Radikal ist, das mit einen bis drei Substituenten ersetzt wird, die von der Gruppe vorgewählt werden, die aus Wasserstoff besteht, (C.sub.1 - C.sub.6)alkyl, (C.sub.1 - C.sub.6)alkoxy ausübt, (C.sub.1 - C.sub.6)alkylthio, (C.sub.2 - C.sub.6)alkenyl, (C.sub.2 - C.sub.6)alkynyl, (C.sub.1 - C.sub.6)alkylhalo, (C.sub.3 - C.sub.8)cycloalkyl, (C.sub.3 - C.sub.8)cycloalkenyl oder Halo; R.sup.1 ist Wasserstoff, (C.sub.1 - C.sub.6)alkyl, (C.sub.1 - C.sub.6)alkoxy, (C.sub.1 - C.sub.6)alkylthio; R.sup.2 ist Phenyl, Naphthyl oder (C.sub.3 - C.sub.12)cycloalkyl ersetzt mit ein oder zwei Substituenten vorgewählt von der Gruppe, die besteht aus Wasserstoff (C.sub.1 - C.sub.6)alkyl, (C.sub.1 - C.sub.6)alkoxy, (C.sub.1 - C.sub.6)alkylthio, (C.sub.2 - C.sub.6)alkenyl, (C.sub.2 - C.sub.6)alkynyl, (C.sub.1 - C.sub.6)alkylhalo, (C.sub.3 - C.sub.8)cycloalkyl, (C.sub.3 - C.sub.8)cycloalkenyl oder Halo; R.sup.3 wird von der Gruppe vorgewählt, die aus Wasserstoff besteht (C.sub.1 - C.sub.6)alkyl, (C.sub.1 - C.sub.6)alkoxy, (C.sub.1 - C.sub.6)alkylthio, (C.sub.2 - C.sub.6)alkenyl, (C.sub.2 - C.sub.6)alkynyl, (C.sub.1 - C.sub.6)alkylhalo, (C.sub.3 - C.sub.8)cycloalkyl, (C.sub.3 - C.sub.8)cycloalkenyl oder Halo; X ist -- (C.dbd.O) --; oder ein pharmazeutisch annehmbares Salz, ein racemate, ein optisches Isomer oder ein solvate davon.

 
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