This disclosure describes isolated or purified deoxyribonucleotide (DNA) sequences, useful for the development of antibacterial agents, which contain the coding sequences of bacterial pathogenesis genes or essential genes, which are expressed in vivo. It further describes isolated or purified DNA sequences which are portions of such bacterial genes, which are useful as probes to identify the presence of the corresponding gene or the presence of a bacteria containing that gene. Also described are hypersensitive mutant cells containing a mutant gene corresponding to any of the identified sequences and methods of screening for antibacterial agents using such hypersensitive cells. In addition it describes methods of treating bacterial infections by administering an antibacterial agent active against one of the identified targets, as well as pharmaceutical compositions effective in such treatments.

Este acceso describe las secuencias aisladas o purificadas del deoxyribonucleotide (DNA), útiles para el desarrollo de los agentes anti-bacterianos, que contienen las secuencias de codificación de los genes bacterianos de la patogenesia o de los genes esenciales, que se expresan in vivo. Describe más lejos las secuencias aisladas o purificadas de la DNA que son porciones de tales genes bacterianos, que son útiles como puntas de prueba para identificar la presencia del gene correspondiente o la presencia de las bacterias que contienen ese gene. También se describen las células extremadamente sensibles del mutante que contienen un gene del mutante que corresponde a cualesquiera de las secuencias y de los métodos identificados de defender para los agentes anti-bacterianos usando tales células extremadamente sensibles. Además describe métodos de tratar infecciones bacterianas administrando un agente anti-bacteriano activo contra una de las blancos identificadas, así como las composiciones farmacéuticas eficaces en tales tratamientos.

 
Web www.patentalert.com

< Hybridization probes derived from the spacer region between the 16S and 23S rRNA genes for the detection of non-viral microorganisms

< Antisense RNA expression strategies effective against Streptococcus thermophilus bacteriophages

> Methods and compositions for designing vaccines

> Hybridization probes derived from the spacer region between the 16S and 23S rRNA genes for the detection of non-viral microorganisms

~ 00092