We have surprisingly discovered that the administration of a G1 and/or S phase drug such as .beta.-lapachone in combination with a G2/M drug such as a taxame derivative such as paclitaxel resulted in an unexpected greater than additive (i.e., synergistic) reduction in the number of tumors (and tumor volume) as compared with the administration of these agents alone. In addition, no signs of toxicity or weight loss were observed. The present invention relates to a method for treating a mammalian tumor using combinations such as a taxane derivative, preferably paclitaxel, and a .beta.-lapachone, or a derivative or analog thereof.

Мы удивительно открывали что администрация G1 and/or с фазируют снадобье such as beta.-lapachone in combination with снадобье G2/M such as производный taxame such as paclitaxel привели к в непредвиденном greater than аддитивном (т.е., синергическом) уменьшении в номере туморов (и тома тумора) по сравнению с администрацией этих веществ самостоятельно. In addition, не наблюдались никакие знаки токсичности или потери веса. Присытствыющий вымысел относит к методу для обрабатывать mammalian тумор использующ комбинации such as производный taxane, предпочтительн paclitaxel, и beta.-lapachone, или производный или аналог thereof.