Compounds having therapeutic utility are of formula (I)
B--X--(CH.sub.2).sub.n --CR.sup.2 R.sup.3 --CR.sup.4 R.sup.5 --COY (I)
wherein
n=0-1;
X is S(O).sub.0-2 ;
Y is OR.sup.1 or NHOH;
R.sup.2 and R.sup.4 are independently H or a group (optionally substituted
with R.sup.10) selected from C.sub.1-6 alkyl, C.sub.2-6 alkenyl, aryl,
C.sub.1-6 alkyl-aryl, heteroaryl, C.sub.1-6 alkyl-heteroaryl,
heterocycloalkyl, C.sub.1-6 alkyl-heterocycloalkyl, cycloalkyl and
C.sub.1-6 alkyl-cycloalkyl; and
R.sup.1, R.sup.3 and R.sup.5 are independently H or C.sub.1-6 alkyl,
provided that not more than two of R.sup.2, R.sup.3, R.sup.4 and R.sup.5
are H; or
any of CR.sup.2 R.sup.3, CR.sup.4 R.sup.5 and CR.sup.2 --CR.sup.4 is a
cycloalkyl or heterocycloalkyl ring optionally substituted with R.sup.10
or a group (optionally substituted with R.sup.10) selected from C.sub.1-6
alkyl, aryl, C.sub.1-6 alkyl-aryl, heteroaryl and C.sub.1-6
alkyl-heteroaryl;
B is heterocycloalkyl (optionally substituted by R.sup.6 or R.sup.7) bonded
through carbon to X, or C.sub.1-6 alkyl-heterocycloalkyl (optionally
substituted with R.sup.6 or R.sup.7), or a group (substituted with
R.sup.6) selected from C.sub.1-8 alkyl, C.sub.2-6 alkenyl and C.sub.2-6
alkynyl;
R.sup.6 is N(R.sup.7).sub.2, OR.sup.7, COR.sup.7, C(.dbd.NOR.sup.9)R.sup.7,
NR.sup.7 R.sup.8, S(O).sub.0-2 R.sup.9 or SO.sub.2 N(R.sup.7).sub.2 ;
R.sup.7 is H or a group selected from C.sub.1-6 alkyl, aryl, C.sub.1-6
alkyl-aryl, heteroaryl, C.sub.1-6 alkyl-heteroaryl, cycloalkyl, C.sub.1-6
alkyl-cycloalkyl, heterocycloalkyl and C.sub.1-6 alkyl-heterocycloalkyl,
wherein said group is optionally substituted with R.sup.9, COR.sup.9,
SO.sub.0-2 R.sup.9, CO.sub.2 R.sup.9, OR.sup.9, CONR.sup.1 R.sup.9,
NR.sup.1 R.sup.9, halogen, CN, SO.sub.2 NR.sup.1 R.sup.9 or NO.sub.2, and
for each case of N(R.sup.7).sub.2 the R.sup.7 groups are the same or
different or N(R.sup.7).sub.2 is heterocycloalkyl optionally substituted
with R.sup.9, COR.sup.9, SO.sub.0-2 R.sup.9, CO.sub.2 R.sup.9, OR.sup.9,
CONR.sup.1 R.sup.9, NR.sup.1 R.sup.9, NR.sup.1 R.sup.9 halogen, CN,
SO.sub.2 NR.sup.1 R.sup.9 or NO.sub.2,
R.sup.8 is COR.sup.7, CON(R.sup.7).sub.2, CO.sub.2 R.sup.9 or SO.sub.2
R.sup.9 ;
R.sup.9 is C.sub.1-6 alkyl, aryl, C.sub.1-6 alkyl-aryl, heteroaryl or
C.sub.1-6 alkyl-heteroaryl; and
R.sup.10 is OR.sup.7, COR.sup.7, CO.sub.2 R.sup.1, CON(R.sup.7).sub.2,
NR.sup.7 R.sup.8, S(O).sub.0-2 R.sup.9, SO.sub.2 N(R.sup.7).sub.2, CN,
halogen or cycloimidyl (optionally substituted with R.sup.1);
and the salts, solvates, hydrates, N-oxides, protected amino, protected
carboxy and protected hydroxamic acid derivatives thereof.
