The invention provides a method for preventing and treating the harmful
biological effects of biochemicals secreted from activated mast cells in
the organism of warm blooded animals and more especially human beings,
said effects being associated with allergy (including but not limited to
allergic conjunctivitis, allergic rhinitis, allergic otitis, asthma,
allergic uticaria, food allergy and atopic dermatitis), hyperproliferative
diseases such as leukemia and systemic mastocytosis, interstitial
cystitis, inflammatory bowel disease, irritable bowel syndrome,
osteoporosis and scleroderma. The method consists in administering to said
animals and especially to human beings an effective amount of a
proteoglycan such as chondroitin sulfate with mast cell secretion
inhibitory activity, alone or in combination with one or more synergistic
adjuvants such those belonging to the class of flavonoids or compounds
with histamine-1 receptor antagonist activity.
