The invention discloses the Neisseria meningitidis NMASP polypeptide,
polypeptides derived therefrom (NMASP-derived polypeptides), nucleotide
sequences encoding said polypeptides, and antibodies that specifically
bind the NMASP polypeptide and/or NMASP-derived polypeptides. Also
disclosed are prophylactic or therapeutic compositions, including
immunogenic compositions, e.g., vaccines, comprising NMASP polypeptide
and/or a NMASP-derived polypeptide. The invention additionally discloses
methods of inducing a immune response to Neisseria meningitidis and
Neisseria meningitidis NMASP polypeptide and an NMASP-derived polypeptide
in animals.