A replication-competent recombinant Sabin type 1 poliovirus vector
containing a sequence coding for multiple cloning site and 3C-protease
cleavage site is provided. This vector makes it easy to introduce various
vaccine genes from infectious viruses to the Sabin 1 poliovirus, and
facilitates to produce chimeric Sabin 1 polioviruses that are expected to
be powerful oral mucosal vaccines against several infectious viral
diseases.
Um tipo recombinant replication-competente 1 vetor de Sabin do poliovirus que contem um coding da seqüência para o local múltiplo do cloning e o local do cleavage 3C-protease é fornecido. Este vetor faz fácil de introduzir vários genes vacinais dos vírus infectious ao Sabin 1 poliovirus, e facilita-o para produzir os polioviruses chimeric de Sabin 1 que se esperam ser vacinas mucosal orais poderosas de encontro a diversas doenças viral infectious.
