The present invention is directed to contulakin-G (which is the native
glycosylated peptide), a des-glycosylated contulakin-G (termed Thr.sub.10
-contulakin-G), and derivatives thereof, to a cDNA clone encoding a
precursor of this mature peptide and to a precursor peptide. The invention
is further directed to the use of this peptide as a therapeutic for
anti-seizure, anti-inflammatory, anti-shock, anti-thrombus, hypotensive,
analgesia, anti-psychotic, Parkinson's disease, gastrointestinal
disorders, depressive states, cognitive dysfunction, anxiety, tardive
dyskinesia, drug dependency, panic attack, mania, irritable bowel
syndrome, diarrhea, ulcer, GI tumors, Tourette's syndrome, Huntington's
chorea, vascular leakage, anti-arteriosclerosis, vascular and vasodilation
disorders, as well as neurological, neuropharmalogical and
neuropsychopharmacological disorders.
A invenção atual é dirigida ao contulakin-G (que é o peptide glycosylated nativo), um contulakin-G DES-DES-GLYCOSYLATED (denominado Thr.sub.10 - contulakin-G), e derivatives disso, a um clone do DNA que codifica um precursor deste peptide maduro e a um peptide do precursor. A invenção é dirigida mais mais ao uso deste peptide como um therapeutic para a anti-apreensão, anti-inflammatory, anti-shock, o anti-anti-thrombus, o hypotensive, analgesia, antipsicótico, doença de Parkinson, disorders gastrointestinal, estados depressive, dysfunction cognitive, ansiedade, discinesia tardive, dependência da droga, ataque do pânico, mania, syndrome irritable do bowel, diarrhea, ulcer, tumors do SOLDADO, syndrome de Tourette, coreia de Huntington, disorders vascular do escapamento, do anti-anti-arteriosclerosis, os vascular e do vasodilation, as.well.as disorders neurological, neuropharmalogical e neuropsychopharmacological.
