Contulakin-G, analogs thereof and uses therefor

   
   

The present invention is directed to contulakin-G (which is the native glycosylated peptide), a des-glycosylated contulakin-G (termed Thr.sub.10 -contulakin-G), and derivatives thereof, to a cDNA clone encoding a precursor of this mature peptide and to a precursor peptide. The invention is further directed to the use of this peptide as a therapeutic for anti-seizure, anti-inflammatory, anti-shock, anti-thrombus, hypotensive, analgesia, anti-psychotic, Parkinson's disease, gastrointestinal disorders, depressive states, cognitive dysfunction, anxiety, tardive dyskinesia, drug dependency, panic attack, mania, irritable bowel syndrome, diarrhea, ulcer, GI tumors, Tourette's syndrome, Huntington's chorea, vascular leakage, anti-arteriosclerosis, vascular and vasodilation disorders, as well as neurological, neuropharmalogical and neuropsychopharmacological disorders.

A invenção atual é dirigida ao contulakin-G (que é o peptide glycosylated nativo), um contulakin-G DES-DES-GLYCOSYLATED (denominado Thr.sub.10 - contulakin-G), e derivatives disso, a um clone do DNA que codifica um precursor deste peptide maduro e a um peptide do precursor. A invenção é dirigida mais mais ao uso deste peptide como um therapeutic para a anti-apreensão, anti-inflammatory, anti-shock, o anti-anti-thrombus, o hypotensive, analgesia, antipsicótico, doença de Parkinson, disorders gastrointestinal, estados depressive, dysfunction cognitive, ansiedade, discinesia tardive, dependência da droga, ataque do pânico, mania, syndrome irritable do bowel, diarrhea, ulcer, tumors do SOLDADO, syndrome de Tourette, coreia de Huntington, disorders vascular do escapamento, do anti-anti-arteriosclerosis, os vascular e do vasodilation, as.well.as disorders neurological, neuropharmalogical e neuropsychopharmacological.

 
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