The present invention provides an antiproliferative compound having a
structural formula
##STR1##
where X and Y independently are oxygen, nitrogen o r sulfur; R.sup.1 is
alkyl, alkenyl, alkynyl, aryl, heteroaryl, carboxylic acid, carboxylate,
carboxamide, ester, thioamide, thiolacid, thiolester, saccharide,
alkoxy-linked saccharide, amine, sulfonate, sulfate, phosphate, alcohol,
ethers or nitriles; R.sup.2 and R.sup.3 are hydrogen or R.sup.4 ; R.sup.4
is methyl, benzyl carboxylic acid, benzyl carboxylate, benzyl carboxamide,
benzylester, saccharide or amine; and R.sup.5 is alkenyl; where when Y is
nitrogen, said nitrogen is substituted with R.sup.6, wherein R.sup.6 is
hydrogen or methyl. Also provided are methods for treating a cell
proliferative disease and for inducing apoptosis in a cell comprising
administering this compound is also provided.
A invenção atual fornece um composto antiproliferativo que tem um ## estrutural onde X e Y sejam independentemente oxigênio, enxôfre do ## STR1 da fórmula do nitrogênio o r; R.sup.1 é alkyl, alkenyl, alkynyl, arilo, heteroaryl, ácido carboxylic, carboxylate, carboxamide, ester, thioamide, thiolacid, thiolester, saccharide, saccharide alkoxy-ligado, amine, sulfonate, sulfate, phosphate, álcool, ethers ou nitriles; R.sup.2 e R.sup.3 são hidrogênio ou R.sup.4; R.sup.4 é methyl, ácido carboxylic benzyl, carboxylate benzyl, carboxamide benzyl, benzylester, saccharide ou amine; e R.sup.5 é alkenyl; onde quando Y for nitrogênio, o nitrogênio dito é substituído com R.sup.6, wherein R.sup.6 é hidrogênio ou methyl. São fornecidos também os métodos para tratar uma doença proliferative da pilha e para induzir o apoptosis em uma pilha compreender administrando este composto é fornecido também.
