A bone substitute material is prepared which comprises a soft matrix,
living cells and a setting matrix comprising non-ceramic hydroxyapatite
cement. The bone substitute material can be injected minimally invasively
into a bone defect with a suitable injection apparatus. In an embodiment,
living cells are mixed with a fibrinogen solution and then with a thrombin
solution to form the soft matrix, and the soft matrix is mixed with an
aqueous solution of non-ceramic hydroxyapatite cement to obtain the bone
substitute material which remains unsolidified until after application to
a body.
