The present invention relates to amphiphilic drug-oligomer conjugates
capable of traversing the blood-brain barrier ("BBB") and to methods of
making and using such conjugates. An amphiphilic drug-oligomer conjugates
comprise a therapeutic compound conjugated to an oligomer, wherein the
oligomer comprises a lipophilic moiety coupled to a hydrophilic moiety.
The conjugates of the invention further comprise therapeutic agents such
as proteins, peptides, nucleosides, nucleotides, antiviral agents,
antineoplastic agents, antibiotics, etc., and prodrugs, precursors,
derivatives and intermediates thereof, chemically coupled to amphiphilic
oligomers.
