This invention relates to compounds of Formula I:
##STR1##
that inhibit the secretion of apolipoprotein B, to pharmaceutical
compositions comprising the compounds, and to methods of treating and/or
preventing atherosclerosis, obesity, diabetes, hyperlipidemia,
hyperliproproteinemia, hypercholesterolemia, hypertriglyceridemia,
hypoalphalipoproteinemia, pancreatitis, myocardial infarction, stroke,
restenosis, or Syndrome X. This invention also relates to methods of
reducing the secretion of apolipoprotein B and/or inhibiting microsomal
triglyceride transfer protein.
Esta invenção relaciona-se aos compostos da fórmula I: ## do ## STR1 isso inibe o secretion do apolipoprotein B, às composições pharmaceutical que compreendem os compostos, e aos métodos de tratar e/ou de impedir o atherosclerosis, o obesity, o diabetes, o hyperlipidemia, o hyperliproproteinemia, o hypercholesterolemia, o hypertriglyceridemia, o hypoalphalipoproteinemia, o pancreatitis, o infarction myocardial, o curso, o restenosis, ou o syndrome X. Esta invenção relaciona-se também aos métodos de reduzir o secretion do apolipoprotein B e/ou de inibir a proteína microsomal de transferência do triglyceride.
