Acetylenic .alpha.-amino acid-based sulfonamide hydroxamic acid tace inhibitors

   
   

Compounds of the formula: ##STR1## are useful in treating disease conditions mediated by TNF-.alpha., such as rheumatoid arthritis, osteoarthritis, sepsis, AIDS, ulcerative colitis, multiple sclerosis, Crohn's disease and degenerative cartilage loss.

Смеси формулы: ## ## STR1 будьте полезн в обрабатывая условиях заболеванием посредничанных TNF-.alpha., such as ревматоидный артрит, остеоартрит, sepsis, AIDS, ulcerative colitis, множественный склероз, заболевание Crohn's и вырожденческая потеря хрящевины.

 
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> Molecular switch for regulating mammalian gene expression

> Non-nucleoside reverse transcriptase inhibitors

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