Controlled-release dosage forms containing an opioid agonist; an opioid
antagonist; and a controlled release material release during a dosing
interval an analgesic or sub-analgesic amount of the opioid agonist along
with an amount of the opioid antagonist effective to attenuate a side
effect of the opioid agonist. The dosage form provides analgesia for at
least about 8 hours when administered to human patients. In other
embodiments, the dose of antagonist released during the dosing interval
enhances the analgesic potency of the opioid agonist.
